Preimplantation Genetic Diagnosis Success Rate
At Los Angeles Reproductive Center, preimplantation genetic screening (PGS) is a normal part of the IVF process. PGS examines embryos before IVF implantation to determine if they have the appropriate number of chromosomes. PGS helps establish embryo quality to increase IVF success.
In some cases, fertility specialists may recommend that patients consider preimplantation genetic diagnosis (PGD) for IVF treatment. PGD is used to identify specific genetic mutations for which a baby may be at risk. Here, our fertility specialists explain the PGD process and PGD success rates for our Encino, CA, Bakersfield, CA, and Los Angeles, CA, IVF patients who are at risk of passing on genetic diseases.
Candidates for Preimplantation Genetic Diagnosis
Our fertility specialists believe that all patients can benefit from PGS, which is why we include it in every IVF procedure. PGD is a more specialized form of preimplantation genetic testing. PGD is explicitly performed to mitigate the risk of passing down a genetic disorder or chromosomal abnormality to your child. Ideal candidates for PGD include:
- Intended parents with a known genetic disorder
- Patients with a prior conception of a chromosomally abnormal child
- Patients with prior unexplained IVF failures
- Patients with a history of recurrent miscarriages
How Is PGD Performed?
PGD is performed after embryos have been nurtured in an IVF laboratory. Typically on day five of fertilization, PGD is performed by removing a small number of cells from each embryo. Cells are carefully extracted by skilled technicians to avoid harming the embryo or making it unviable. Extracted cells are analyzed to determine the presence of specific genetic or chromosomal abnormalities.
How Does PGD Benefit IVF Patients?
PGD benefits IVF patients by lowering the chance of passing on specific genetic diseases to increase the chance of a healthy pregnancy. More specifically, PGD allows our fertility specialists and patients to:
- Identify embryos that carry a genetic condition and avoid implantation of affected embryos
- Allow genetic disorder carriers to significantly decrease their risk of passing disorders on to their children
- Identify the strongest embryos to improve the chance of a successful pregnancy
- Make decisions regarding embryo implantation and pregnancy based on the health of available embryos
PGD Success Rates
Currently, there is no collected data to track the overall success rate of IVF treatment with PGD. However, the National Library of Medicine published an analysis of IVF outcomes with PGD, focusing on 106,902 IVF cycles. Of the evaluated IVF cycles, 9,833 were performed with PGD. Based on the study’s findings, PGD was shown to increase the odds of live birth among women over the age of 37 and decrease the odds of miscarriage for women aged 35-37 when performed for aneuploidy (the occurrence of one or extra or missing chromosomes) screening.
Fertility specialists at Los Angeles Reproductive Center offer a wide range of services and treatments to address infertility and increase the chance of a healthy pregnancy. To learn how PGD may be beneficial to you on your journey to parenthood, contact our fertility clinic online or call (818) 946-8051 and schedule an appointment.